labarai

Dangane da kwarangwal aza-BODIPY, NIR1001 yana haɗa ƙungiyoyin ba da gudummawa ta lantarki (misali, 4-N, N-diphenylaminophenyl) a wurare 2,6, suna samar da tsarin D-π-D mai ma'ana1. Wannan ƙira yana taƙaita tazarar HOMO-LUMO, yana jujjuya kololuwar sha fiye da 1000 nm kuma yana haɓaka canja wurin cajin intramolecular (ICT). A cikin THF, NIR1001 yana nuna matsakaicin ɗaukar hoto biyu (TPA) na 37 GM, haɓaka sau biyu akan abubuwan BODIPY na gargajiya. Rayuwar sa mai farin ciki-jihar na 1.2 ps yana ba da damar ingantacciyar sauye-sauye marasa radiyo, yana mai da shi dacewa da maganin photodynamic (PDT).

Ƙididdigar DFT ta nuna cewa tsarin canja wurin caji na NIR1001 ya taso ne daga π-electron delocalization tsakanin masu ba da gudummawa da masu karɓa. Gyaran methoxy yana ƙara haɓaka shayarwar NIR a cikin tagar phototherapeutic (650-900 nm), haɓaka hankali1. Idan aka kwatanta da rini na AF na Jami'ar Fudan, NIR1001 tana kula da ƙananan nauyin kwayoyin halitta (<500 Da) tare da 40% mafi girma na hoto. Gyaran Carboxylation yana inganta narkewar ruwa (cLogD = 1.2), yana rage ƙayyadaddun adsorption a cikin tsarin ilimin halitta.

3. Aikace-aikace na Biomedical
A cikin bioimaging, hCG-conjugated bincike hCG-NIR1001 ya cimma babban ƙuduri na hoto na ovarian follicles da micro-metastases a karkashin 808 nm tashin hankali. Tare da zurfin shigar ciki na 3 cm a cikin NIR-II, ya zarce binciken NIR-I da ninki uku, yayin da yake rage hasken baya da kashi 60%. A cikin samfurin raunin koda na linzamin kwamfuta, NIR1001 yana nuna 85% na musamman na koda, gano lalacewa sau shida da sauri fiye da sarrafa macromolecular.
Don PDT, NIR1001 yana haifar da nau'in oxygen mai amsawa (ROS) a 0.85 μmol/J a ƙarƙashin 1064 nm irradiation laser, yadda ya kamata ya haifar da apoptosis cell tumor. Liposome-encapsulated NIR1001 nanoparticles (NPs) yana tara sau 7.2 fiye da ciwace-ciwacen ciwace fiye da rini kyauta, yana rage tasirin kashe-kashe.
4. Kula da Masana'antu da Muhalli
A cikin aikace-aikacen masana'antu, NIR1001 an haɗa shi cikin Juhang Technology's SupNIR-1000 analyzer don rarraba 'ya'yan itace, kimanta ingancin nama, da sarrafa taba. Yin aiki a cikin kewayon 900-1700 nm, yana auna abun ciki na sukari lokaci guda, danshi, da ragowar magungunan kashe qwari a cikin daƙiƙa 30 tare da daidaito ± (50ppm + 5%). A cikin na'urori masu auna firikwensin CO2 (ACDS-1001), NIR1001 yana ba da damar saka idanu na ainihi tare da lokacin amsawar T90≤25s da tsawon shekaru 15.
Don gano mahalli, NIR1001 masu aikin bincike sun gano ƙarfe masu nauyi a cikin ruwa. A cikin pH 6.5-8.0, ƙarfin walƙiya yana daidaita daidai da haɗin Hg²⁺ (0.1-10 μM) tare da iyakar ganowa na 0.05 μM, haɓaka hanyoyin launi ta umarni biyu na girma.
5. Ƙirƙirar Fasaha da Kasuwanci
Qingdao Topwell Materialsyana aiki da ci gaba da kira don samar da NIR1001 a 99.5% tsarki, tare da 50 kg/batch iya aiki. Yin amfani da reactors na microchannel, ana rage lokacin kwantar da Knoevenagel daga sa'o'i 12 zuwa mintuna 30, yana yanke amfani da makamashi da kashi 60%. Jerin ISO 13485-certified NIR1001 ya mamaye kasuwar ilimin halittu.